We aim to train pharmacists who pursue medicine by digging into it scientifically.
The Faculty of Pharma-Science has more than 30 laboratories. Current students study on various research themes in a laboratory instructed by the pharmacy department of Teikyo University Hospital, a laboratory aiming to develop vaccine preparations, a laboratory conducting research on drugs and side effects, and so on.
Pharmaceutical Chemistry Course
Main research contents Research on the structure and function of functional proteins that play an important role in life support and the causative proteins of diseases
Laboratory introduction Our laboratory is one of the constituent laboratories of the Pharmaceutical Chemistry Course. In terms of education, we are in charge of basic physical chemistry for 1st graders, physical chemistry 3 for 2nd graders, physical chemistry lectures for 4th and 6th graders, and physical chemistry training for 2nd graders. In addition, we are also in charge of the special lecture on biomolecular physical characteristics at the Graduate School. It is important to understand the structure and function of biomolecules, which play an important role in life support, and pharmaceuticals and chemical substances that act on living organisms from the molecular level on the viewpoint of physical chemistry. This also leads to a deeper understanding of other pharmacy specialty subjects. In addition, as part of our graduation research, our laboratory has been conducting research on biomolecules from the above perspectives and has achieved good results.
Synthesis, physical properties, and reactivity of the above metal complexes (heme, etc.)
Laboratory introduction We are mainly in charge of lectures on "Physical Chemistry 1" in the second half of the first grade and "Physical Chemistry 2" in the first half of the second grade. "Physical Chemistry" is a field where we theoretically study chemical phenomena using physical or mathematical methods. It is often mistaken for physics, but the content is chemistry taught in high school. Nearly half of contents taught in high school chemistry, including theoretical chemistry (solution concentration, heat of reaction and thermochemical equations, batteries), substance structure and state (material three states, gas properties, solution properties), and reaction rate and equilibrium, etc. are in the scope of physical chemistry in the university. The only difference from high school chemistry is that students think more theoretically using mathematical formulas and graphs. We support the understanding of these physical chemistry fields through lectures and practical training.
Development of a simple quantification method for biological components using fluorescence reaction
Search and application of novel functional peptides latent in biological components
Laboratory introduction "Analytical chemistry" is the basis of all research, and no research can proceed without "analysis" and "measurement". In other words, "analytical chemistry" can be developed into any research. The lectures and practical training of our laboratory focus on quantitative analysis, instrumental analysis and calculation problems, and have a lot of basic contents. In the laboratory, students are doing research ahead of the world. Our laboratory creates a cozy atmosphere so that students can easily stop by. A variety of staff with a wealth of life experience conducts daily lectures, regular exam consultations, career / employment talks, and even life consultations.
Main research contents We conduct research related to "gout and hyperuricemia" such as measurement of purines in foods.
Laboratory introduction We are in charge of lectures and practical training. We are in charge of lectures include instrumental analysis (Kaneko-first term in 2nd grade), clinical analysis (Kaneko-first term in3rd grade), pharmacognosy (Yamaoka-first term in 3rd grade), natural product chemistry (Yamaoka-second term in 3rd grade), introduction to Chinese medicine (Yamaoka-first term in 4th grade), clinical nutrition (Yamaoka- intensive lecture in 5th grade), pharmacognosy frontline 2 (Kaneko-intensive lecture in 5th grade), community medicine theory 2 (Yamaoka-intensive lecture in 5th grade), as well as an advanced course lecture in 4th grade and comprehensive lectures in 6th grade individually or in a shared manner. As for the training, we are in charge of analytical training (Kaneko, Yamaoka and Fukuuchi) and pharmacognosy training (Yamaoka) in pharmacognosy training 2 (first term in 2nd grade).
Laboratory introduction The Metabolic Chemistry Laboratory is a new laboratory that was just opened in April 2018, and conducts education and research in collaboration with the Drug Discovery Chemistry Laboratory. Our laboratory's research field is bioorganic chemistry, and students can deeply study the specialized field of organic synthesis, or they can touch a wide range of academic fields that include biochemistry and analytical chemistry beyond the boundaries of their specialty. In our laboratory, we are working on research with the goal of synthesizing an artificial nucleic acid called peptide nucleic acid (PNA) and putting it into practical use as a pharmaceutical product. PNA recognizes the base sequences of DNA and RNA and inhibits the action of unfavorable genes. We would like to use PNA to develop new treatments to overcome previously difficult diseases such as cancer and viruses. In addition, PNA can accurately identify slight differences in genes, so it is also useful as a diagnostic agent for detecting gene mutations that cause diseases. Gene mutations in proteins involved in drug transport and metabolism are greatly affected by individual differences in drug effects and side effects, so if these mutations are found before drug administration, drug treatment can be made safer and more effective.
Main research contents We discover the mechanism by which a drug takes a three-dimensional structure and binds to enzymes and receptors in the body to exert its effect.
Laboratory introduction Our laboratory specializes in synthetic organic chemistry, and aims to train future researchers and pharmacists by studying a wide range of subjects from the basics of organic chemistry to difficult reactions. Most of the medicines are organic compounds. Therefore, it is very important for drug experts to understand the characteristics and properties of medicine from the structural formula. Each student in the laboratory has a different theme and think and work on the experiment by himself. By synthesizing compounds using the reactions learned in textbooks, they can feel organic chemistry closer to them. Therefore, students who are not good at organic chemistry can enjoy learning. [Course] 1st grade: Invitation to Pharmacy 1, Basic Chemistry, Organic Chemistry 1 2nd grade: Pharmacy Training 3 3rd grade: Medicinal Chemistry 1, Natural Product Chemistry 4th grade: Basic Pharmacy 2 (Chemistry), Drug Development 5th grade: Forefront of Pharmacy 3 6th grade: General Lecture 2 (Chemistry), General Seminar
Main research contents Research to capture the potential of vitamin D derivatives as pharmaceuticals in a new phase
Laboratory introduction In our laboratory, we are in charge of "organic chemistry" education for second graders through lectures in the morning and pharmacy training in the afternoon. The second graders start learning more about the addition reaction of alkene that we learned in high school, and advance to the world of chemistry that carbon and oxygen create, such as chemistry of aromatic compounds like benzene, substitution reaction and desorption reaction of alkyl halide, hydroxy group and ether bond, and the carbonyl group of aldehydes and ketones. By learning the reactions used in the chemical synthesis of pharmaceuticals and the basic properties of functional groups contained in pharmaceuticals, we focus on developing scientific capabilities that should be demonstrated as pharmacists in the medical field in the future. In terms of research, vitamin D derivatives are currently used clinically as therapeutic agents for osteoporosis, psoriasis, secondary hyperparathyroidism, etc., but we also focus on anticancer effects, immunomodulatory effects, and effects on the brain and nervous system. We conduct research aiming for the world's first novel derivative structure with remarkable efficacy without side effects.
Main research contents Research to clarify the brain mechanism of memory and learning at the molecular level
Laboratory introduction In our laboratory, we are conducting research to elucidate the intracerebral mechanism of memory and learning at the molecular level. In terms of education, we are in charge of lectures such as "Molecular Biology" and "Immunity / Microbiology" and pharmacy practice 7 "Opportunistic Infection and Molecular Biology Testing". In "Molecular Biology", students acquire the structure and function of genes, which are the programs of life, basic knowledge about metabolism, and skills and attitudes related to genetic manipulation. In "Immune / Microbiology", students learn the structure and properties of bacteria, viruses, fungi, etc., the immune system that protects you from these pathogenic microorganisms, and typical diseases and drugs. In "Opportunistic Infection and Molecular Biological Testing", students detect the bacteria that acquired resistance to antibiotics by molecular biological methods, and experienced what they learned in lectures through experiments.
Main research contents Exploring the functions of genes involved in gastric formation, cancer, and obesity, and trying to elucidate the mechanism
Laboratory introduction Some people may think that the chemistry that synthesizes medicines is the main thing when it comes to the Faculty of Pharma-Science. But it is more important for pharmacists to understand "how a drug works" than to know a drug as a compound. The faculty members of our laboratory are in charge of lectures and practical training courses related to biology and biochemistry, which are the basis for understanding "how medicines work" from the first grade. Therefore, we strive every day to give lectures and practical training that can be understood immediately after becoming pharma-science students and that will be useful even after becoming pharmacists.
Main research contents Research on the response mechanism of living organisms to environmental chemical substances, especially harmful and essential heavy metals
Laboratory introduction Humans ingest and excrete various chemical substances in the environment from food, water and air. Some of them are necessary nutrients but some are harmful, and even medical drugs are detected in the environment and become a problem. In other words, chemical substances circulate in the global environment through the human body, and the environment and humans are inseparably integrated. Based on this concept, our laboratory is in charge of lectures on the environment such as "Science of Life and Environment" and "Environmental Hygiene". In addition, we investigate at the genetic level how the cells of living organisms respond to zinc which is an essential mineral as an environmental chemical, and cadmium and mercury which are harmful heavy metals, with the aim of clarifying their biological significance. Students in the 4th grade and above are participating in the graduation research.
Main research contents Studies on the effects of phospholipid metabolism on cell function and bioactive substances derived from phospholipids
Laboratory introduction The discipline "Biochemistry" is a study that seeks to understand the works of life at the molecular level. All the events that occur in the body are made up of the involvement (interaction and reaction) of various molecules (biomolecules). Medicine is also a molecule and acts by intervening in the reaction of biomolecules. Therefore, biochemistry is the most basic and important discipline that forms the basis for a deeper understanding of the effects of life and medicine. At the Biochemistry Laboratory, we are focusing on lipids among biomolecules. It is learned in various lectures on pharmacy that lipids are not only as nutrients but also related to various phenomena and diseases that are important for living organisms. The research theme of the biochemistry class is "to clarify the mechanism of life phenomena and diseases through metabolism of phospholipids and lysophospholipids".
Main research contents We conduct research on the relationship between the physiological functions and pathological conditions of new bioactive lipids such as 2-arachidonoylglycerol (2-AG) and lysophosphatidylinositol (LPI) found in our laboratory.
Laboratory introduction Sanitary chemistry is a chemistry that "protects life" and prevents various diseases caused by various substances and pathogens contained in foods and drinking water ingested in the body, and a field of hygiene and pharmacy which aims to maintain and promote human health. In our laboratory, there are lectures on nutrition chemistry in the 2nd grade and hygiene chemistry in the 3rd grade. In nutrition chemistry, students learn about the metabolism and function of nutrients contained in foods, and the current intake of nutrients in Japan. In sanitary chemistry, students learn about food poisoning, food additives, and foods with health function. As a practical training, there is a part of pharmacy training 6 in the 3rd grade. In addition, there is also a part of the special lecture on hygiene and pharmacy in the 4th grade and the general lecture 4 "Hygiene" in the 6th grade.
Main research contents Analysis of the mechanism of adverse effects caused by drug poisons
Laboratory introduction Toxicology is the field of science of the effects of natural and chemical substances to living organisms. In today's world of chemical substances, knowledge of their health effects is indispensable as a pharmacist. In our lecture (toxicology), students learn about the pharmacokinetics of chemical substances, the mechanism of adverse effects and test methods, and the law that regulates chemical substances. In addition, in the student training, students will deepen their understanding through experiments on detection methods for harmful metals, harmful gases, pesticides, stimulants, etc. For students assigned to the laboratory, through the process of reading English dissertations in their specialized fields, conducting experiments on given research themes, and compiling graduation thesis, theoretical thinking ability, problem-finding / problem-solving ability, and self-improvement. I am cultivating my abilities.
Involvement of plasma and intracellular PAF acetylhydrolases in drug metabolism
Protective role of plasma-type PAF acetylhydrolase against oxidative stress
Role of intracellular PAF acetylhydrolase in immune response
Laboratory introduction The Molecular Pharmaceutics Laboratory is in charge of lectures and practical training on pharmaceuticals for undergraduate students. In addition to learning the basic knowledge about the design of pharmaceutical products in lectures, we deepen our understanding by actually practicing the drug product test method for evaluating the efficacy and safety of pharmaceutical products. In the laboratory assignment from the 4th grade, each student is given a research theme according to the research content of the laboratory, and the research results are summarized and announced as a graduation thesis in the 6th grade. Laboratory staff provide in-depth and kind guidance to assigned students so that they can acquire the ability to pass the pharmaceutical common exam and the national pharmacist exam. During the laboratory life, there are laboratory trips in which all faculty members and students participate. Through the above, all the laboratory staff hope to send graduates out who can contribute to society as medical professionals.
Main research contents Research on eye diseases (cataracts, diabetic retinopathy, etc.). In particular, elucidation of the pathogenic mechanism of intraocular diseases induced by diabetes and treatment, and development of preventive drugs.
Laboratory introduction Lecture in charge: Hiroshi Osano (Professor) "Pharmaceutical Informatics 1 (Latter term in the 3rd grade), Pharmacotherapy (1st term in the 4th grade)", "Radiopharmaceuticals (Latter term in the 3rd term)", "Invitation to Pharmacy 2 (Latter team in the 1st grade) ". Yoshiki Miyata (Senior Assistant Professor) "Radiopharmaceuticals (Latter the 3rd grade)", "Language Exercises (the 3rd grade)". In addition, we conduct student training and graduation thesis guidance. Laboratory education policy: we enrich the roof tile type education and environment of research based on the policy of "looking back on the way (junior) while looking forward the way (senior)" with 4th to 6th grade students in the laboratory. What I want to convey is that "the only testimony of what we have learned is to change." Even if we spend together just one day, we would like to nurture a heart that feels a big change. We hope to show our students that they can survive strongly in any environment.
Peroxisome disease, as a congenital lipid metabolism disease
Arteriosclerosis foam cells
Laboratory introduction Pharmaceutics is a study that deals with what dosage form (tablets, capsules, ointments, injections, etc.) should be selected for a drug to show its efficacy, and how to maintain the drug concentration in the body. Of these, in the physical pharmaceutics conducted by our laboratory, students learn about the physical properties that are the basis of various dosage forms and modifications. Specifically, we research the properties of powder, the rate of drug dissolution, the viscosity of the ointment, and the stability of the drug. By mastering physics pharmaceutics, students may find that it is really skillfully applied to the basis of drug handling in the medical field. The goal is to be able to dispense based on theory in this way. The lectures is given in the first half of the 2nd grade, and the practical training is given in the second half.
Main research contents Research aimed at preventing lifestyle-related diseases by focusing on food
Laboratory introduction In our laboratory, we aim to train "pharmacists who have the ability to solve various problems that occur in the medical field" and provide guidance. In particular, in graduation thesis research, we instruct students by the aim of developing their own plans, finding problems, and acquiring the ability to deal with them. In addition, in order to make people feel the importance of working as a team, we also practice activities in groups that are organized beyond the boundaries of the grade, with acceptance of other's opinions and ideas, and expression of their own opinions together. In the lecture, we teach information on lifestyle-related diseases, blood and hormonal diseases and medicines used for these diseases, and convey the significance of clinical tests, and contribute to the establishment of knowledge base for drug treatment.
Main research contents Creation of seranostics system by bubble formulation and ultrasonic wave (THE RANOSTICS is a phrase consisting of Therapeutics (treatment) and Diagnostics (diagnosis), and both treatment and diagnosis are performed at the same time.)
Laboratory introduction We are in charge of lectures on biopharmaceutics (the 3rd grade) and drug discovery (the 4th grade). The content of the lecture is about a high-tech drug called drug delivery system (DDS) in technical term, which controls the movement of medicine in the body. For example, it finds the location of cancer and aiming at it with medicines to treat it, sends genes to kill cancer, or boosts one's own immune system to overcome cancer. In addition, we explain the development of a system that can diagnose and treat at the same time using DDS technology. Young ideas are very important here. Knowledge of DDS becomes more and more important for the pharmacists students aim to become.
Main research contents Research aimed at elucidating the mechanism of drug transfer to the human brain and individualizing appropriate treatment of central therapeutic agents
Laboratory introduction 【Education】 Our laboratory is in charge of lectures on pharmacokinetics that quantitatively analyze the in vivo fate (absorption, distribution, metabolism, excretion) of drugs. Pharmacokinetics is a discipline necessary to maximize the effects of drugs and avoid side effects, and is widely applied to the development of drugs and the proper use of drugs in clinical practice. In pharmacy practical training, we are in charge of training to learn the role of pharmacists in Team Medical Care, such as creating administration plans according to the individual patient's condition. Through such lectures, practical training, and research activities, we strive to develop human resources with problem-solving abilities and to develop pharmacists with scientific viewpoints.
【Research】 The brain has a blood-brain barrier that separates it from blood and protects it from drugs and poisons. The transfer of drugs to the brain is controlled by the function of the transport system of the blood-brain barrier. In our laboratory, we conduct research to elucidate the function of the blood-brain barrier and the mechanism of drug transport to aim to develop next-generation drugs and to use them individually and appropriately. In addition, we also research on clinical pharmacokinetics based on the brain transfer mechanism of opioid analgesics.
Main research contents We research the mechanism of protecting the body from cancer and active oxygen, focusing on white blood cells.
Laboratory introduction In the lecture, I am in charge of digestive disorders, cancer, and immune disorders. Specifically, students learn about the characteristics of diseases and therapeutic agents for gastrointestinal diseases such as the esophagus, stomach, large intestine, pancreas, bile sac and liver, and also cancers of various organs, and moreover autoimmune diseases such as rheumatoid arthritis. All diseases have a very large number of patients, and pharmacists must perform important duties as a member of Team Medical Care. Therefore, our goal is to acquire a wide range of knowledge so that students can contribute as a pharmacist. In addition, in the student's practical training, under the theme of cancer and antineoplastic drugs, we conducted an experiment to transplant cancer into mice and inject antineoplastic drugs to see the effect, and experience the knowledge gained in the lecture about cancer and the effect of the drug on cancer.
Elucidation of new cardiomyocyte regeneration mechanism
Elucidation of the onset mechanism of cardiomyopathy
Elucidation of control mechanism of myocardial ion channel
Laboratory introduction This is a laboratory that conducts research and education on "pharmacology". Pharmacology is a discipline that comprehensively studies where and how medicines work in the body and how they effect to the body. In order to understand the mechanism of medicines' effect, it is also important to understand the mechanism of healthy body and the mechanism of getting sick. Therefore, in our laboratory, we search for genes that cause heart disease and investigate how they lead to the disease. We also conduct research to find out what kind of treatment can be used to regenerate the heart and cure the disease. Acquiring knowledge and ideas of pharmacology through such research become a great power to save patients in front of you when you become a pharmacist who is required to have a wide range of knowledge and application skills regarding medicines.
Main research contents Study on the effects (main effects and side effects) of drugs acting on the nervous system and the mechanism of their expression
Laboratory introduction 【Education】 Our laboratory locates on the 7th floor of the Itabashi Campus of University Building in Jujo, and is in charge of lectures on pharmacology and physiology. And we are also in charge of practicing pharmacology using animals. 【Research】 We conduct the following research mainly in the 5th grade students assigned to our laboratory. (1) Comparative study of anticholinergic effects as side effects of drugs (2) Study on the effects of anticholinergic drugs at the neuromuscular junction (3) Research on the mechanism of dyskinesia expression and its overcoming, which is one of the problems in drug treatment of Parkinson's disease.
Study on Alport syndrome (COL4A5, 4A3, 4A4 gene mutation)
Study on uric acid transporter (SLC22A12 gene)
Laboratory introduction Lecture Introduction to Medicine: Each symptom and over-the-counter drug (medicine that can be purchased without a prescription) Lecture Physiology 2: Functions of cells and body other than nerves Lecture Pathology and Pharmacology 1: Psychiatric, diseases of nervous and sensory organ ,and its remedies Lecture Advance Course on Medical Pharmacy 2: Neuropharmacology Lecture Advance Course on Medical Pharmacy 3: Medical Bioethics Lecture General Lecture 5: Neuropharmacology Lecture General Lecture 8: Medical Bioethics Seminar Communication 4: Blood pressure measurement exercise Seminar Human Communication: Small Group Education Practical training Pharmacy practical training 2: Biological practical training (bacterial culture, mouse anatomy) Practical training Practical training of human anatomy observation: Observation of human anatomy Practical training Graduation research: The research conducted for 11 weeks according to the research content of the laboratory
Main research contents Development of vaccine product
Laboratory introduction Newly synthesized organic compounds and proteins produced by genetic recombination cannot be used as pharmaceuticals as they are. It is necessary to maximize the effectiveness of these substances and devise ways to prevent side effects. In addition, as products, it is necessary to devise ways to maintain stability and sterility. Pharmaceutical science is discipline which studies these sciences comprehensively, and our laboratory provides education on the pharmaceutical science. Pharmaceutical science is an applied study unique to pharmacy and is one of the disciplines that pharmacists must fully understand. In particular, in recent years, vaccine preparations for cancer treatment have been attracting attention, and we conduct research and education on new types of immune preparations.
Research on safety management and proper use of pharmaceutical products
Research on the mechanism of drug formulation change and its toxicity
Research on information analysis based on actual drug usage
Laboratory introduction The Professor, Associate Professor, and Senior Assistant Professor of our laboratory also serve as the director or deputy director of the pharmacy department of Teikyo University Hospital. In our laboratory, we are in charge of lectures and practical trainings on pharmacist's practice such as drug business 1 and drug epidemiology in the 5th grade, and general lecture 8 "Practice" in the 6th grade. In the laboratory, we focuse on seminars and case studies. The seminar focuses on learning the basic clinical thinking process as a pharmacist. We have a systematic and logical step-by-step approach to drug treatment monitoring in small seminar groups. We aim to cultivate the practical ability to provide appropriate pharmaceutical care to patients by conducting more specific case studies.
Laboratory introduction In the Hospital Pharmacy Laboratory, Professor, Associate Professor, and Senior Assistant Professor concurrently serve as the director or deputy director of the pharmacy department of Teikyo University Hospital. Therefore, we aim to improve the clinical ability of pharmacists who can respond to the transition of medical care in the future by providing education directly connected to medical sites such as hospitals and exploring research themes. Regarding education, in addition to the conventional dispensing ,formulation and drug management operations, as drug therapy has become more sophisticated with the progress of medical technology, we aim to educate pharmacists who can demonstrate sufficient expertise in the medical field as a member of Team Medical Care. In other words, we aim to educate pharmacists who can independently intervene in improving the quality of drug treatment by proper use of drugs, ensuring medical safety. Regarding research, we collaborate with pharmacists, doctors and co-medical staff in clinical site to search for pharmacist-led clinical research, and conduct research and guidance on issues that are appropriate for medical site. In addition, we conduct practical education and research guidance for the training of medical personnel who is responsible for regional Team Medical Care in collaboration with hospital and pharmacy pharmacists (pharmaceutical collaboration). Through these education and research, we as pharmaceutical experts would like to contribute to society and train pharmacists who are expected and trusted by patients and medical staff.
Laboratory introduction Regional Health Pharmacy is a new laboratory opened in April 2018. In the super-aging society, Japan has built comprehensive community care system, and the assignment of pharmacists is in a period of change. Regional medicine is medical care related to people's daily lives, and pharmacists work with other occupations and related organizations to centrally and continuously grasp information such as the patient's medication status, and required to provide optimal pharmaceutical care and give guidance based on it. In order to solve such problems, our laboratory is engaged in the following researches.
Establishment of collaborative methods between pharmacies and medical institutions based on Protocol Based Pharmacotherapy Management (PBPM), and evaluation research of outcomes
Research on the geographical distribution of pharmacists
Research on pharmacokinetics and drug efficacy or toxicity in pathological conditions
