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A research group Senior Staff Professor Kozuma has gained new insights into strategies for early discontinuation of aspirin.
Itabashi Campus

A research group led by Professor Ken Uezuma, Senior Staff the Department of Clinical Medicine and Internal Medicine at Teikyo University School of Medicine, investigated antiplatelet therapy for the treatment of acute myocardial infarction in a large-scale randomized clinical trial, the first of its kind in Japan, at 69 medical institutions nationwide. The results showed that the method using "low-dose prasugrel monotherapy" resulted in fewer major bleeding events compared to conventional DAPT using aspirin, but there was a tendency for more myocardial infarction recurrence.
This study demonstrates the need to consider the balance between bleeding prevention and thrombosis prevention in relation to the patient's condition and treatment stage, rather than simply thinking of antiplatelet therapy as merely "reducing the dosage." In particular, it is considered to provide important insights into reconsidering the role of aspirin during the period of high thrombosis risk immediately after myocardial infarction.
Furthermore, the results of this research were published on August 29, 2026 (Saturday) in "The New England Journal of Medicine," a leading medical journal published by the Massachusetts Internal Medicine Surgery Society in the United States.

The press release for this research can be found here.
Senior Staff here for information about Professor Uezuma.

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