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Lecturer Michishi, Faculty of Pharmacy, Itabashi CampusSenior Assistant Professor Faculty of Pharma-Science elucidated a part of the mechanism by which hypothermia therapy protects the brain.

Through joint research with Yuto Natori, an Assistant Professor at the Nagoya University Graduate School of Faculty of Pharma-Science, Doshikatsu, a Senior Assistant Professor in the human body's functional morphology at Teikyo University's Faculty of Pharmaceutical Sciences, has elucidated part of the mechanism by which hypothermia therapy protects the brain.
Hypothermia therapy has already been applied clinically, but its mechanism is not clear, so its effectiveness varies depending on the case. This time, we compared metabolites in the hippocampus of the brain using a mouse model in which hypothermia (34°C) can prevent the death of neurons in the hippocampus, and a model mouse with normal body temperature (37°C). However, we discovered that adenosine monophosphate and xanthosine monophosphate are metabolites that increase due to hypothermia. The results of this research are expected to lead to the establishment of effective protocols for hypothermia therapy and, in the future, to the development of new brain-protective drugs.
The results of this research were published in Springer Nature's "Scientific Reports" on Wednesday, February 7, 2024.

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